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For infection of the perineum and genitals (Fournier gangrene), trauma, surgery, urinary tract infection, stones, and Bartholin gland abscess are the usual causes.Types of soft-tissue necrotizing infection can be divided into four classes according to the types of bacteria infecting the soft tissue.Another bacterium with similar rapid progression is group A streptococcal infection (mostly Streptococcus pyogenes).Meanwhile, other bacterial infections require two or more days to become symptomatic.While a number of laboratory and imaging modalities can raise the suspicion for necrotizing fasciitis, the gold standard for diagnosis is a surgical exploration in the setting of high suspicion.When in doubt, a small incision can be made into the affected tissue, and if a finger easily separates the tissue along the fascial plane, the diagnosis is confirmed and an extensive debridement should be performed.This creates an acidic, oxygen deficient environment for the proliferation of bacteria.

Alpha toxins cause excessive platelet aggregation which blocks blood vessels and deprives the vital organs of oxygen supply.

For reasons that are unclear, it occasionally occurs in people with an apparently normal general condition.

Necrotizing fasciitis can occur at any part of the body, but it is more commonly seen at the extremities, perineum, and genitals.

Those with clostridial infections typically have severe pain at the wound site, where the wound typically drains foul-smelling blood mixing with serum (serosanguinous discharge).

Shock can progress rapidly after initial injury or infection, and once the state of shock is established, the chance of dying exceeds 50%.

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Usually, trauma is not the cause of such infections.